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KMID : 0357319730080010037
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Journal of the Korean Society for Microbiology
1973 Volume.8 No. 1 p.37 ~ p.42
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A Study on the Immune Response of Salmonella Typhi Inactivated by Gamma Ray
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李康淳/Rhee, Kang Soon
閔鳳熙/張正淳/Min, Bong Hee/Chang, Chung Soon
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Abstract
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For the preparation of non-infective vaccine against typhoid fever, the authors had carried out an investigation on the possibilities of using 60Co y-ray irradiation for the inactivation of Salmonella typhi Ty 2.
The following results were obtained.
1) Chicks shortly after hatching were higher susceptible than mice to intracerebral injection with S. typhi.
2) In safety test on experimental animal, 6pCo 7--ray irradiated vaccines demonstrated no clinical symptom while the phenol treated vaccines revealed several cases of narcosis by intraperitoneal injection in chicks.
3) The rabbit antisera immunized with 60Co y-ray irradiated and phenol treated vaccine revealed almost same agglutinin titers to each other.
4) In potency test in chicks, there was no significance in the protective capacity between 60Co y-ray irradiated and phenol treated vaccines.
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KEYWORD
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